What are the functions of flippases and phospholipid translocases?
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med's go on Instagram: "Phosphatidylserine is normally located on the inner leaflet of the plasma membrane, maintained there by ATP-dependent flippases. During apoptosis, this asymmetry is lost and phosphatidylserine flips to the outer leaflet, where it serves as an “eat-me” signal for macrophages. This externalization allows recognition and phagocytosis of apoptotic cells without triggering inflammation, making phosphatidylserine a classic marker of programmed cell death #pathology #apoptosis #
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