Small molecule-based immunomodulators for cancer therapy
Dec 1, 2022 · Immunotherapy has led to a paradigm shift in the treatment of cancer. Current cancer immunotherapies are mostly antibody-based, thus possessing advant…
Immunomodulators - Cancer Research Institute
Currently, the FDA has approved 16 different immunomodulators—nine checkpoint inhibitors, four cytokines, two adjuvants, and a small molecule with immunomodulatory properties—for the …
Small molecule innate immune modulators in cancer therapy
Sep 10, 2024 · In this review, we discuss about various small molecule modulators (Summarized in Table 1) of targets such as STING/ENPP1, TLR, NLRP3, and SIRPα-CD47 which are key …
Non-specific cancer immunotherapies and adjuvants - Oral Cancer …
Non-specific immunotherapies don’t target cancer cells specifically. They stimulate the immune system in a more general way, but this can still sometimes lead to a better immune response …
Definition of nonspecific immune stimulation - NCI Dictionary of Cancer …
A type of cancer therapy that works by stimulating the immune system in a general way rather than by targeting cancer cells specifically. It may also help the body fight infection and other …
Immune Modulation and Immunotherapy in Solid Tumors: …
Mar 24, 2025 · We also explored various mechanisms contributing to immunotherapeutic resistance, emphasizing how modulating specific immune cells with immune modulators can …
Non-targeted (Non-specific) Immunotherapies - Healio
Currently, the two main cytokines used during cancer treatment are Interferon alpha (IFN-alpha), which slows cancer cell growth, and interleukin-2 (IL-2), which signals the immune system to...
Recent developments in myeloid immune modulation in cancer therapy
Myeloid cells play a crucial dual role in cancer progression and response to therapy, promoting tumor growth, enabling immune suppression, and contributing to metastatic spread. The ability …
The potential of immunomodulators in shaping the future of …
Sep 3, 2024 · Innovative therapies like checkpoint inhibitors, CAR T-cell therapy, and cancer vaccines have revolutionized oncology by leveraging the immune system's capabilities.
A new immunotherapy approach could work for many types of cancer
14 hours ago · Using molecules called AbLecs that block an immune checkpoint, researchers showed they could stimulate a strong anti-tumor immune response. The approach, which …