In this study, the duration of enzyme induction provoked by unlabelled lactose ureide (LU) in orocaecal transit time (OCTT) measurements with lactose-[13 C]ureide (13 C-LU) was evaluated. Without ...

A team of mathematicians and pharmaceutical scientists collaborated to identify the major cause of the low accuracy of the equation in the FDA guidance used to predict drug-drug interaction through an ...

British Journal of Industrial Medicine, Vol. 38, No. 1 (Feb., 1981), pp. 91-97 (7 pages) To determine the effect of petroleum exposure on the activity of hepatic mixed function oxidase enzymes, ...

PNAS is the world's most-cited multidisciplinary scientific serial. It publishes high-impact research reports, commentaries, perspectives, reviews, colloquium papers, and actions of the Academy. In ...

Drugs are metabolized in the liver using several enzyme-catalyzed processes. These enzymes are collectively referred to as the hepatic microsomal enzyme system, and they are usually present in the ...

Researchers Explore a Number of Strategies to Better Predict Drug Responses in the Clinic As drug development costs continue to escalate, determining toxicity and possible interactions with foods, ...

Induction of Cell Senescence by NSD2 Inhibition (IMAGE) Kumamoto University Caption The NSD2 enzyme acts to prevent cell aging. LEFT: Suppression of the NSD2 gene in fibroblasts arrested cell ...